| abstract |
The invention relates to a method and an apparatus for producing oligomers and arrays of oligomers, the synthesis method being expanded by an additional neutralization step. This enables the protective groups to be removed without carry-over, which allows deprotection of the oligomers at precisely defined positions on the support material. For this method, a new type of microelectromechanical device is used which, through the integration of reaction chambers (13) and several liquid metering elements (1, 4, 5, 7, 8) in one chip, enables precise addressing on a carrier material in the form of a one- or multi-dimensional array allowed. The solution according to the invention is intended to create a possibility of creating oligomers or arrays of oligomers which, on the one hand, are positioned exactly in the smallest space and at the same time have a minimal error rate in the generation of the by the neutralization step and the thus prevented distribution of the deprotection agent to positions that are not to be deprotected Has sequences of the oligomers. With the aid of the device according to the invention, the possibility should additionally be created to realize the production of oligomers and their arrays in a short time with little effort. |