http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-05815687-T1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2aa388e460f6cf478bd46c925c6ab10e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-81 |
| filingDate | 2005-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_019e2e24f5c9e6f15d5b31f3fc7c56d6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a71e559a7929f0651c8b72bcb8fa9788 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f387c79a0591081cc4e597fb59abddcd |
| publicationDate | 2007-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-05815687-T1 |
| titleOfInvention | PROCESS FOR PREPARING CITALOPRAM AND ENANTIOMERS |
| abstract | A process for the preparation of 1- [3- (dimethylamino) propyl] -1- (4-fluorophenyl) -1,3-dihydro-5-isobenzofurancarbonitrile which comprises reacting a compound of formula IVa in the presence of a base with a compound of Formula RX, Formula IVa wherein R is selected from alkyl, alkenyl, aryl and heteroaryl, which may be optionally substituted with electron-withdrawing groups, and X is selected from F, Cl, Br, I, CN, OTf and OR 1 , wherein Tf is a trifluoromethanesulfonyl R 1 is optionally substituted alkyl, Z is a cyano group or a group which can be converted to a cyano group; wherein RX is selected such that an ether derivative obtained as an intermediate, a compound of formula Va formed by the reaction, cyclizes to a compound of formula VI, Formula Va Formula VI and wherein Z is not a cyano group, and converting the group Z in the compound of the formula VI into a cyano group to give 1- [3- (dimethylamino) propyl] -1- (4-fluorophenyl) 1,3-dihydro-5-isobenzofurancarbonitrile. |
| priorityDate | 2004-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.