http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DD-301740-A7
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da9c519bc5d52cdf9e2c478e123d9f7b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P33-00 |
| filingDate | 1990-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1993-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DD-301740-A7 |
| titleOfInvention | Method for the microbial degradation of sterols to ndrosta-1,4-diene-3,17-dione |
| abstract | The invention relates to an improved process for the microbial degradation of sterols to androsta-1,4-diene-3,17-dione (ADD) by degradation of the side chain. The compound ADD is known as an intermediate of sterol degradation and serves as a key product for the production of a range of steroid drugs. The object of the invention to initially produce ADD crude products with high analytical product formation rates and high molar yields whose AD by-product content is so low that ADD of high purity is obtained by simple preparative workup, is achieved in that for a microorganism of the species Mycobacterium vaccae a defined management of the seed culture is used, which is accompanied by a specific alkalization as metrologically detectable parameter. After fermentation of the main culture in a manner known per se and after separation of other accompanying substances, the target product ADD is then obtained in high purity by simple work-up (crystallization). {Microbial degradation of sterols; Microorganism Mycobacterium vaccae; defined management of the seed culture; Major product androsta-1,4-diene-3,17-dione (ADD); high product formation rate; low androst-4-ene-3,17-dione fraction (AD)} |
| priorityDate | 1990-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.