http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DD-298277-A5
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84f626c67a21089e624199aa26a0d1d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d5fe74855697fef20a2e98a9b005db19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a290ec33a99086be0fcc552ecf78ad22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P33-08 |
| filingDate | 1988-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc8718f69bd34a95b5a3a466dde04142 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e65fd199bc0386f77cccb2a7e637cfb4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bb31ac7ee2b3b3af1248a17858d6865 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f58cef9b96a5e9f4c819af18c4c8449f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72fb67aac87f92b5557aae2e3dc724e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fef1dcea318504c3c9752bcb96dbc822 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_657bf35e8b9bf4b9f5a2af661beca574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a5269aab247b1f9b3dda5f4dd65f73c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6b815f496ad5c95f146addc890cd87b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba9fc066a92cd5ac7a02eff27910ba8f |
| publicationDate | 1992-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DD-298277-A5 |
| titleOfInvention | PROCESS FOR MICROBIAL PRODUCTION OF PREDNISOLONE-17-ACETATE |
| abstract | The invention relates to a process for the microbial production of prednisolone 17-acetate and relates to a process for the microbial transformation of the pregnane series, which are esterified in the 17 and 21-position or esterified only in 17a-position, to prednisolone-17- acetate, d. H. to 17a-acetoxy-11b, * This microbial transformation is an advantageous variant for the production of glucocorticoids, especially prednisolone. Prednisolone is a highly effective drug for the treatment of allergies, rheumatoid arthritis, asthma, dermatoses and the like. a. According to the invention, the microorganism is provided with an adequate amount of energy in the form of carbohydrates, in particular glucose, in the form of carbohydrates, in particular glucose, from the time of the highest product formation rate until the end of the fermentation, with sufficient ventilation. The beginning of the glucose dosage takes place at the latest, if the CO2 content of the exhaust air has a minimum. The cyanide-sensitive respiratory route of the cells is used as an indicator of an oxidative metabolism layer for Prozeszkontrolle by the respiratory activity of the cells is measured polarographically in a known manner. The pO2 content can be 30% from the beginning of the glucose dosage. The glucose dosage is carried out in amounts of 30 to 100 mg, preferably 40 to 50 mg glucose / g biomass dry weight x h. Particularly suitable are the strains Cochliobolus lunatus 148, Absidia orchides 409 or Absidia coerulu 468. {prednisolone production; Prednisolone 17-acetate; microbial 11b hydroxylation; esterified * of the pregnane series; Cochliobolus lunatus 148; Absidia orchids 409; Absidia coerula 468; Energy supply, continuous; Carbohydrates} |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112143771-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112143771-A |
| priorityDate | 1988-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.