| abstract |
The invention relates to a process for the preparation of piperazine derivatives of the general formula in which X is CO, OCO, OCO 2, N (R 7) CO, NHNHCO, ON (R 7) CO, * N (R 7) CO 2, OCON (R 7) or N ( R7) CON (R8) is; R1 to R8 have different meanings; n stands for one of the integer values 1, 2, 3, 4 or 5; or pharmaceutically-acceptable salts thereof, with the proviso that when X is an alkyl group for CON (R7) and R7, R6 is not simultaneously a 2-pyrimidinyl residue. These compounds act as antidepressant and / or anxiolytic agents. Formula {procedures; manufacture; piperazine derivatives; tertiary alkyl groups; 5-HT1A receptors; D2 receptors; anxiolytic agent; antidepressant agent; antipsychotic agent; pharmaceutical agent} |