| abstract |
Novel imidazole derivatives of the formula (Ia) in which R1, R2, R1 and R2, which may be identical or different, are H, CH3, C2H5, C3H7, OCH3, OH, CH2OH, NO2, NH2, CN, CF3, CHF2 , CH 2 F or halogen; R is H or R3 is H, CH3 or halogen; R4 is H, R5 is H or OH, R6 is H or OH and R7 is H or R4 and R6 together form a bond or R5 and R7 together form a bond; X and Y, which may be the same or different, are a bond, a C1-2 alkyl or the corresponding alkenyl, and z is 0-2, and formula (I b) wherein R1, R2, R1, R2 and R R4 is H or OH and R5 is H or R4 and R5 together form a bond and y is 0-4 and their non-toxic salts show aromatase and desmolase inhibiting properties. Very selective aromatase inhibiting compounds are valuable in the treatment of estrogen-dependent diseases, for example breast cancer. Formulas (I a) and (I b) |