| abstract |
The invention relates to a technically feasible process for the preparation of * in high yield, of very good quality and crystallinity, which is characterized in that ampicillin, ampicillin salts or hydrolytically easily cleavable esters with * as a technical solution in a chlorinated organic solvent such as methylene chloride in the presence of Acid is acidified and during or after Ansaeuerung in a two-phase system water / organic solvent, wherein the organic solvent is a mixture of chlorinated hydrocarbon and esters, such as ethyl acetate, with pure seed crystals of * is added. The reaction product precipitates in this way in high yield and constant very good purity from the reaction mixture, is very easy to isolate and handle technically. {Piperacillin; acylation; ampicillin} |