| abstract |
This invention relates to novel 3-substituted 2-oxindole derivatives which are inhibitors of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. The compounds of the invention are useful as inhibitors of prostaglandin H2 synthase and interleukin-1 biosynthesis as such and as analgesic, anti-inflammatory and antiarthritic agents in the treatment of chronic inflammatory diseases. This invention also relates to pharmaceutical compositions containing these 3-substituted-2-oxindole derivatives; A method of inhibiting prostaglandin H2 synthase and biosynthesis of interleukin-1 and treating chronic inflammatory diseases in a mammal with these compounds. Furthermore, the invention relates to certain novel carboxylic acids useful as intermediates in the preparation of 3-substituted-2-oxindole derivatives of this invention and a process for the preparation of the 3-substituted-2-oxindole derivatives. {Oxindole derivatives; inhibitors; prostaglandin; synthase; interleukin; Biosynthesis, anti-inflammatory, antiarthritic; Mammals; carboxylic acids} |