| abstract |
The invention relates to a process for the preparation of vaccines for the prophylaxis of HIV infection, using recombinant surface proteins or hybrid particles of HIV, which are obtained by a genetic engineering method, which comprises a gene coding for the corresponding surface protein, or a Part of the gene in the reading phase to the 3-end of at least part of the Pre S2 region of the HBV genome ligated, which part is so large that it encodes an immunogenic protein, this fusion DNA molecule to an expression control sequence of an expression vector functionally ligated, the resulting recombinant DNA molecule in a eukaryotic host organism einschleust, zue the resulting transformed host organism in a culture medium and isolated from the cell lysate or culture medium, the protein or the hybrid particle. {HIV; Oberflaechenprotein gene; Oberflaechenprotein; Hybrid particles; Expression vector; Recombinant DNA; Detection of induced antibodies; Prophylaxis; Vaccine against HIV infections} |