abstract |
The invention relates to a method for the production of vaccines for the prophylaxis of Plasmodium infections, using recombinant surface proteins or hybrid particles of Plasmodium, which are obtained by a genetic engineering method, which comprises a Plasmodium gene coding for the corresponding surface protein or ligating a portion of the gene in reading phase to the 3-terminus of at least a portion of the Pre S2 region of the HBV genome, which portion is so large as to encode an immunogenic protein, to a fusion DNA molecule Functionally ligating the expression control sequence of an expression vector, introducing the resulting recombinant DNA molecule into a eukaryotic host organism, culturing the resulting transformed host organism in a culture medium and isolating the protein or the hybrid particle from the cell lysate or culture medium {Plasmodium; Oberflaechenprotein gene; Oberflaechenprotein; Hybrid particles; Expression vector; Recombinant DNA; Detection of induced antibodies; Prophylaxis; Vaccine against Plasmodium infections} |