| abstract |
The invention relates to a process for the preparation of temperature-resistant crystalline salts of 7- [alpha (2-aminothiazol-4-yl) -alpha - () - methoxyiminoacetamido] -3 - [(1-methyl-1-pyrrolidinio) methyl] -3 -cephem-4-carboxylate selected from sulfuric acid, di-nitric acid, mono- and di-hydrochloric acid addition salts and ortho-phosphoric acid addition salts containing 1.5 to 2 molar equivalents of H 3 PO 3. The process of the invention is carried out by a) preparing a mixture of the appropriate amount of acid and the acid and the witterion, b) inducing the crystallization of the addition salt, c) isolating the crystalline addition salt, and d) if desired, converting the addition salt into the hydrate , The salts obtainable according to the invention have excellent stability at room temperature and are therefore useful for the preparation of medicaments used in medicine for combating infections. |