http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DD-282918-A5
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c89cdb408a39eb40fc69d27627685b9e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-813 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-06 |
| filingDate | 1988-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e2e8268b7bc17b2540120319c9bda48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_037f18f82c7bc6392c7fc4405059e094 |
| publicationDate | 1990-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DD-282918-A5 |
| titleOfInvention | ENZYMATIC PROCESS FOR THE PREPARATION OF PEPTIDES, ESPECIALLY DIPEPTIDES AND DEVICE THEREFOR |
| abstract | The invention relates to an enzymatic process for the preparation of peptides, in particular dipeptides, and a device therefor. The compounds of the invention may possibly play an important role in parenteral nutrition in the future. Optionally N-protected peptides, in particular dipeptides, are obtained by continuous enzymatic reaction of N-protected amino acid alkyl ester in the presence of serine protease or peptidase, in particular carboxypeptidases, in the aqueous phase with exclusion of organic solubilizers and with retention of the enzyme in the reaction space with such an excess Amino acids (mol ratio 50: 1) and such a residence time, which lead to the quantitative conversion of the ester to form the N-protected peptide, which is separated from the outgoing from the reaction space reaction mixture by adsorption on a hydrophobic adsorber, while the amino acid-containing radical of the reaction mixture back to the reaction room. From the adsorber, the N-protected peptide is eluted with aqueous solution and then enzymatically desacylated. Peptide formation and deprotection are preferably carried out in the enzyme membrane reactor or with carrier-fixed enzyme. The N-protected amino acid ester used is in particular N-phenacetylamino acid alkyl ester, whose protective group is enzymatically cleaved off with penicillin G acylase. The reaction of N-protected aromatic amino acid ester with free aliphatic amino acid (in particular formation of TyrAla) was particularly investigated. Continuous operation provides an increase in the economics of peptide synthesis. {Peptides; Dipeptide production, enzymatic; Enzyme membrane reactor; Working method, continuous; Economy, improved; Nutrition, parenteral} |
| priorityDate | 1987-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.