| abstract |
The invention relates to a process for the preparation of phosphorus-containing compounds which inhibit the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase and are thus suitable as hypocholesterolemic agents. The compounds of the present invention have the following formula in which R represents a hydroxyl group or a salt thereof or a lower alkoxy group, Rx represents a hydrogen atom or an alkyl group, X represents one of (CH 2) a, CHCH, CC or CH 2 O (wherein the O is bound to the radical Z), a has the value 1, 2 or 3 and Z represents a hydrophobic anchor. Formula {HMG-CoA reductase inhibitors; Cholesterol biosynthesis; phosphorus-containing compounds; Medicine; Cholesterol; lowering agents, lipid level lowering agents; Method} |