| abstract |
The invention relates to a process for the preparation of a particular sulfonamide. Prepared are compounds of formula (A) and their salts wherein R a is NO 2, NH 2 or NHSO 2 R 1, wherein R 1 is a C 1 -C 4 alkyl group; R b is NO 2, NH 2 or R 3, where R 3 is NHSO 2 (C 1 -C 4 alkyl) or CONR 4 R 5 wherein R4 and R5 are each independently H or C1-C4 alkyl or, together with the nitrogen atom to which they are attached, a 1-pyrrolidinyl, piperidino, morpholino or N-methylpiperazin-1-yl group; with the proviso that when one of the substituents Ra and Rb is NO 2, then the other is not NH 2; X is O, S or a direct bond; Y is an ethylene group optionally substituted by a methyl group; "alk" is an ethylene, Trimethylene or tetramethylene group, wherein "alk" is optionally substituted by a methyl group; RC1-C4 alkyl; andR2H, halo, CF3 or C1-C4 alkyl. The compounds of formula (A) wherein Ra is NHSO2R1 and Rb is R3, wherein R1 and R3 are as defined above, are antiarrhythmic cardiac agents. The remaining compounds of formula (A) are synthetic intermediates. Formula (A) |