| abstract |
Improved process for the preparation of 2,4,6,8-tetrahydroxypyrimido & 5,4-d! Pyrimidine and its salts. 2,4,6,8-Tetrahydroxypyrimido & 5,4-d! Pyrimidine or its salts are obtained in crystalline form in high purity and yield, in good separable form and in terms of environmental protection with better conditions, by the condensation reaction between urea and 5 -Aminouracilcarbonsaeure- (4) in the presence of triethylbenzylammonium chloride performed. Furthermore, as an inert solvent or Verduennungsmittel polyether alcohol having an average molecular weight of 1 000 to 4 000 are used. The resulting target compound, which is a valuable intermediate of the chemical-pharmaceutical industry, contains no more starting material, nor in the remaining reaction solution. |