http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DD-248028-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07c273645af222a938f4da0b5465ef9e |
| filingDate | 1984-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a21ae77a0cf53d390235033b591ea5e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3010077ab4b3270e1ae100245167c06d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da05bed206205ed783c052a0cb87c5a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e8191c050256b7708926e28f1da8a3a |
| publicationDate | 1987-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DD-248028-A3 |
| titleOfInvention | PROCESS FOR THE PREPARATION OF (S) -PHENYLALANINE DERIVATIVES |
| abstract | The invention relates to the improvement of a process for the preparation of (S) -N-acyl-phenylalanines, in particular of the aromatic radical in 3,4-position 0-functionalized derivatives by catalytically asymmetric hydrogenation prochiral unge unsettled precursors in the presence of chiral metal complex catalysts. The hydrogenation products are easy to convert into (S) -phenylalanine or its derivatives. According to the invention, alcohol solvates of a (Z) -2-N-acylamino-3-arylacrylic acid are used as prochiral unsaturated substrates, resulting in optical yields up to when using the particularly suitable cationic rhodium (I) complex catalysts with carbohydrate bis (phosphinic acid esters) as chiral chelate ligands 95% of (S) -N-acyl-3-arylalanine can be achieved even when using high molar ratios of substrate catalyst in excess of one thousand, which was prevented in the case of the previously attempted use of solvate-free substrates by reaction inactivation. As a further advantage, an increase in the reaction rate is achieved in two to ten times. |
| priorityDate | 1984-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.