| abstract |
Preparation of 9- or 11-nitroapovincamic acid derivatives of the general formula (I) in which R is a group of the general formula -CO-X, in which X is halogen, or represents a group of the general formula -CO-OR1, in which R 1 is an optionally mono- or polysubstituted aliphatic hydrocarbon group having 1-10 carbon atoms, a cycloaliphatic hydrocarbon group having 3-8 carbon atoms or an aromatic hydrocarbon group having 6-14 carbon atoms, or is a group of the general formula -CO-NR 2 R 3, in which R 2 and R 3 independently of one another represent hydrogen or alkyl groups having 1-8 carbon atoms which optionally form a further nitrogen atom or heteroatom-containing heteroatom-containing hetero ring with the adjacent nitrogen atom, with the result that in the case of R 2 H R 3 also an amino group can be, or stands for a cyano group, as well as the salts these connections. The new compounds have a vasodilating, spasmolytic, antihypoxic and anticonvulsant action. Formula (I) |