| abstract |
The invention relates to a process for the preparation of substituted isochromans and oxepins for use as medicaments. The aim of the invention is the provision of compounds with stronger, in particular calcium-antagonistic and anti-hypertensive action. According to the invention, compounds of the general formula (I) are prepared in which, for example, R 1 is a hydrogen atom or a C 1 -C 4 -alkyl group, R 2 is a hydrogen atom or a C 1 -C 4 -alkyl group and the like. a, R 3 is a hydrogen atom or a C 1 -C 4 -alkyl group, R 4 is a hydrogen atom or a C 1 -C 4 -alkyl group, R 5 is a hydrogen atom or a C 1 -C 6 -alkyl group having 1 to 6 C atoms or a pyridinyl group, R 6 is a hydrogen atom, a fluoro, Chlorine or bromine atom, a straight or branched C1-C6-alkyl group u. a., R7 is a hydrogen atom, a fluorine, chlorine or bromine atom, a straight or branched C1C6-alkyl group u. a, R8 is a hydrogen atom, a hydroxy or alkoxy group, m1 or 2n1, 2 or 3, and their acid addition salts. |