| abstract |
2- (pyridyl and imidazolyl) -indoles of the formula Iworin R 1 is hydrogen or lower-alkyl, Ar is in each case unsubstituted or lower-alkyl, carboxy, lower-alkoxycarbonyl or carbamoyl-substituted 3-pyridyl or 1-imidazolyl, R 2 and R 3 independently of one another are hydrogen, lower alkyl, Halogen, trifluoromethyl, hydroxy, lower alkoxy, carboxy-lower alkyl, lower alkoxycarbonyl-lower alkyl, carboxy, lower alkoxycarbonyl or lower alkyl (thio, sulfinyl or sulfonyl), or R2 and R3 together, on adjacent carbon atoms, are lower alkylenedioxy; A alkylene having 3 to 12 carbon atoms, wherein the number of carbon atoms present between the indole nucleus and the group B is 3 to 12, alkenylene or alkynylene each having 2 to 12 carbon atoms, lower alkylene-phenylene-lower (alkylene or alkenylene), lower alkylene-phenylene, Lower alkylene (thio or oxy) lower alkyl, lower alkylene (thio or oxy) phenylene or lower alkylenephenylene (thio or oxy) lower alkylene; and B represents carboxy, esterified carboxy, carbamoyl, mono- or di-lower alkylcarbamoyl, hydroxymethyl, cyano, hydroxycarbamoyl , 5-tetrazolyl or formyl, their imidazolyl or pyridyl N-oxides, and their salts inhibit thromboxane synthetase. They are produced in a manner known per se. |