| abstract |
The invention relates to a process for the preparation of novel substituted piperazin-1-yl-acetic acid amides for use as medicaments, for example for the control of cerebral insufficiency. The aim of the invention is to provide new compounds with more favorable pharmacological data than piracetam. According to the invention, an analogy method for preparing substituted piperazin-1-yl-acetic acid amides of the formula I is provided by R1, e.g. As phenyl, pyridyl, thienyl, furyl, amino, alkylamino, phenylamino, or alkoxy, R2 z. As amino, alkylamino, dialkylamino, morpholino, 4-methyl-piperazinyl- (1), pyrrolidinyl- (1), piperidino, diethanolamino, dipropanolamino, where z. B. a piperazine-1-y-acetic acid amide of the formula II is reacted with an acylating agent which introduces the acyl radical R1-CO- in the compound II. |