| abstract |
A process is described for the preparation of novel 2-2-Naphthylglycylamidocephalosporins with the formula (I), wherein R is high 1 for one of the three resulting from the formula sheet bicyclic radicals, wherein R is high 7 and R is high 8 hydrogen, halogen , Hydroxy, C deep 1-C deep 4-alkyl, C deep 1-C deep 4-alkoxy, nitro, amino, C deep 1-C deep 4-alkanoylamino, C deep 1-C deep 4-alkylsulfonylamino or together are methylenedioxy , A and B are hydrogen or a double bond. R 2 is hydrogen, an amino protecting group, hydroxy or methoxy, R 3 is hydrogen, R 4 is hydrogen, methoxy or methylthio, R 5 is hydrogen, methoxy, methyl, halogen or methoxymethyl, and R 6 is hydrogen or a carboxy-protecting group, and pharmaceutically-acceptable salts thereof by known per se. Known o. known per se starting materials, Preferred Verbindg. of this type are sodium D-7- (2-naphthylglycylamido) -3-chloro-3-cephem-4-carboxylate, 7- (6-chloronaphth-2-ylglycylamido) -3-methyl-3-cephem-4-carboxylic acid or D-7- (2-naphthylglycylamido) -3-methyl-3-cephem-4-carboxylic acid. |