| abstract |
The invention relates to a process for the preparation of new cephalosporins having a strong antibacterial activity. The aim of the invention is the provision of cephalosporins with improved activity against gram-positive and gram-negative microorganisms. According to the invention, new cephalosporins of the general formula I are prepared in which, for example: Y is hydrogen or methoxy; A is the phenyl, 4-hydroxy-phenyl, 3,4-dihydroxyphenyl or d. 2- or 3-thienyl group or others; D hydrogen, d. Acetoxy or aminocarbonyloxy group, d. Pyridinium or 4-aminocarbonylpyridinium group or others; R d. Group -NHR deep 2 means in which R deep 2 may be an optionally substituted pyridyl, pyrimidinyl, thienyl, furyl, thienylmethyl, imidazolylmethyl, thiazolylmethyl, pyridylmethyl or pyrimidinylmethyl radical u. E is hydrogen or a protecting group and their salts with inorganic or organic bases. |