| abstract |
A process for the preparation of pharmacologically valuable 3,4-bis-substituted 1,2,5-oxadiazole-2-oxides of the formula I and their pharmaceutically acceptable acid addition compounds wherein R = -NHR 1, -NR 2 R tall 3, -NHR 4 or higher high 2, -NHR high 5 COR HIGH 6, -NXR high 1 = alkyl with 1 to 6 C atoms, cycloalkyl with 4 to 7 C atoms, R high 2, R high 3 = alkyl with 1 to 4 C atoms R 4 = an alkylene radical of the formula -C deep n H deep 2n -, where, 2,3 or 4, R 5 = an alkylene radical of the formula -C deep m H deep 2m -, where m is 1,2 or 3 R is high 6 = -OR high 2, -NHR high 1, -NR high 2 R high 3, -NH deep 2, X = - (deep CH 2) deep p -, - (deep CH 2) deep 2-O - (CH t ief 2) deep 2 -, - (CH deep 2) deep 2-N-high R2- (CH deep 2) deep 2- p = 4,5 or 6, by elimination of hydrogen chloride from a Hydroxamoylchlorid the formula II and dimerization and optionally subsequent conversion into the acid addition compound. |