| abstract |
The invention relates to a process for the preparation of 1-subst.-6-n-propyl-8-methylimidazo & 1,5-d! as-triazine-4 (3H) ones, which have proven to be excellent anti-asthmatic agents. To prepare, for example, -5-dimethyl-2-n-propyl-4-imidazolemethanol, 2-n-propyl-5-methyl-4-imidazolecarboxaldehyde is dissolved in tetrahydrofuran under argon at 0 ° C. and stirred, while 3M is methylmagnesium bromide in the course of 20 minutes. Later, hydrochloric acid is added to decompose the magnesium salts. The mixture is then saturated with solid ammonium chloride, filtered and purified. |