http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DD-153208-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_08f659eb3038ba9f6c519bc4f245be9a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27819572d3790a00ae62019e39177717 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D457-06 |
| filingDate | 1980-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2d7bc6ddce0156fd55ac6210da2f39c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a4a0916e5ca4ae59b09a646277eb1fd |
| publicationDate | 1981-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DD-153208-A1 |
| titleOfInvention | METHOD FOR PRODUCING N- (LYSERGYLAMINOACYL) LACTAMES |
| abstract | A simple process for the preparation of N (lysergyl-aminoacyl) -lactams is described in which the N-terminal amino acid of the peptide portion in N-protected form is condensed under peptide-chemical conditions directly with the dipeptide-lactam. In this way, depending on the type of amino acid derivative and dipeptide lactams used, a wide variety of N-substituted alpha-aminoacyl-dipeptide-lactams are available, which serve as valuable intermediates for the synthesis of the peptide portion of ergot alkaloids including the cyclol moiety. After cleavage of the N-protecting group, the aminoacyl-dipeptide-lactam can be acylated with d-lysergic acid, 9,10-dihydrolysergic acid or their modification products and so a large number of pharmacologically interesting alkaloids of N- (d-lysergyl-aminoacyl) -dipeptid-lactam Synthesize type. Alternatively, these compounds are also accessible by first substituting the N-terminal amino acid of the peptide portion with the d-lysergyl, 9,10-dihydrolysergyl residue or corresponding derivatives thereof and then coupling it to the dipeptide lactam by peptide chemistry. |
| priorityDate | 1980-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.