| abstract |
The invention relates to a process for the preparation of amidines and their salts, especially of N, N, N'-trisubstituted benz, pival or adamantamidines of the formula I, wherein R & exp1! substituted phenyl, R & exp2! and R & exp3! Alkyl groups with 1 to 4 carbon atoms or an alkylene group (CH & ind2!) & Indn! with n = 2-6 or the oxapentamethylene group. The aim of the invention is the preparation of amidines with biological, especially antiviral effect. These compounds are e.g. by activation of N-substituted carboxylic acid amides of substituted or unsubstituted benzoic acid, pivalic acid or adamantanecarboxylic acid with SOCI & ind2 !, PCI & ind5! or also POCI & ind3! and to obtain further reaction with suitable secundary or primary amines. The free amidines are optionally converted into salts. Formula. |