| abstract |
The invention relates to a process for the preparation of mercapto-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines with dopamine receptor neutralizing activity for use as medicaments, in particular as antipsychotics and antiemetics. The aim of the invention is to provide a simple and economical method for Herstellungsg. of these connections. According to the invention, compounds d. Formula I produced, where R & ind1! Phenyl, m- or p-substituted phenyl and the substituent is trifluoromethyl, chloro, methoxy, methyl, fluoro, nitro or hydroxy, cyclohexyl, thienyl, thienylmethyl, furyl or furylmethyl; both R & ind2! Methoxy, alkanoyloxy with an alkanoyl moiety having 2 to 6 carbon atoms or hydroxy and R '& ind3! Is hydrogen, bromine, fluorine and trifluoromethyl, or a non-toxic pharmaceutically acceptable acid addition salt of this compound. |