| abstract |
The invention relates to a process for the preparation of corticoid 21-sulfopropionates. The aim of the invention is the provision of corticoid derivatives which are slightly water-soluble, form stable sterilizable solutions and rapidly develop their full activity on application. According to the invention, corticosteroid 21-sulfopropionates of the general formula I are prepared, in which St represents the steroid nucleus of an anti-inflammatory corticosteroid, but in particular corticoid 21-sulfopropionates of the general formula II, in which for example: .... single bond or double bond; X is hydrogen, chlorine, fluorine, methyl, Y is hydrogen, fluorine, chlorine; Z is an oxo group, a hydrogen atom, a hydroxy group and many other groups as well as their salts with physiologically harmless bases. |