http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DD-146186-A5
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 |
| filingDate | 1978-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8ef2d33d5a1b883061c71c91f141cf1 |
| publicationDate | 1981-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DD-146186-A5 |
| titleOfInvention | PROCESS FOR PREPARING A 4A, 9B-HEXAHYDRO-YPSILONE COMPOUND |
| abstract | The invention relates to a process for the preparation of a hexahydrocarboline compound of formula VI and the pharmaceutically acceptable salts thereof, wherein the hydrogen atoms bonded to the carbon atoms in the 4a and 5b positions are in a trans-arrangement with each other, X and Y are the same or are different and are hydrogen or fluorine, n is 3 or 4 and Z is hydrogen, fluorine or methoxy. These compounds are suitable as transquillizers. According to the invention, the free base of certain 4a, 9b-trans-hexahydro-carboline compounds is acylated with a selected carboxylic acid or an acid chloride or acid bromide thereof to obtain a 4a, 9b trans-hexahydro-carboline compound which reacts with lithium aluminum hydride in the presence an inert solvent is reduced. One possible final product is d & ind1! -Trans-2- (4-hydroxy-4-phenylbutyl) -5-phenyl-2,3,4,4a, 5,9b-hexahydro-1H-pyrido & 4,3-b! -Indole hydrochloride by the mentioned reduction of d & ind1! trans-2 - & (3-benzoyl) -propronyl)! - 5-phenyl-2, 3, 4, 4a, 5,9b-hexahydro-1H-pyrido & 3,3-b! indole is obtained. |
| priorityDate | 1977-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.