| abstract |
The present invention relates to piperidine derivatives of formula (I), wherein R<1> is a C1-4alkoxy group; R<2> is formula (a); R<3> is a hydrogen or halogen atom; R<4> and R<5> may each independently represent a hydrogen or halogen atom, or a C1-4alkyl, C1-4alkoxy or trifluoromethyl group; R<6> is a hydrogen atom, a C1-4alkyl, (CH2)mcyclopropyl, -S(O)nC1-4alkyl, phenyl, NR<7>R<8>, CH2C(O)CF3 or trifluoromethyl group; R<7> and R<8> may each independently represent a hydrogen atom, or a C1-4alkyl or acyl group; x represents zero or 1; n represents zero, 1 or 2; m represents zero or 1; and pharmaceutically acceptable salts and solvates thereof; to processes for their preparation; and their use in the treatment of conditions mediated by tachykinins. |