http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-82195-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-1024 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0202 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0207 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0205 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-023 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-117 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-083 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-61 |
| filingDate | 1995-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a91cef0dfc2d0e7b4c99b82b429792d0 |
| publicationDate | 1996-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CZ-82195-A3 |
| titleOfInvention | Inhibitors of farnesyl-protein transferase containing imidazole nucleus |
| abstract | Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected by compounds of the formula <CHEM> their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs, and solvates, wherein: G is <CHEM> <CHEM> G<1> is <CHEM> G<2> is <CHEM> or -NR<1><0>-CH(Q<1>)-; J, K and L are each, independently, N, NR<9>, O, S or CR<1><0> with the provisos that only one of the groups J, K and L can be O or S, and at least one of the groups J or L must be N, NR<9>, O or S to form a fused five-membered heteroring; the bond between J and K or K and L may also form one side of a phenyl ring fused to the fused five-membered heteroring; Q is aryl; Q<1>, A<1> and A<2> are each, independently, H, alkyl, substituted alkyl, phenyl or substituted phenyl; G<3> is R<1><1>, -C(O)OR<1><1>, -C(O)NR<1><1>R<1><2>, 5-tetrazolyl, -C(O)N(R<1><3>)OR<1><1>, -C(O)NHSO2R<1><4> or -CH2OR<1><1>; G<4> is <CHEM> attached at the 1, 2, 4 or 5 position and optionally substituted, at any of the available position or positions on the ring, with halo, alkyl or substituted alkyl having 1 to 20 carbon atoms, alkoxy, aryl, aralkyl, hydroxy, alkanoyl, alkanoyloxy, amino, alkylamino, dialkylamino, alkanoylamino, thiol, alkylthio, alkylthiono, alkylsulfonyl, sulfonamido, nitro, cyano, carboxy, carbamyl, N-hydroxycarbamyl, N-alkylcarbamyl, N-dialkylcarbamyl, alkoxycarbonyl, phenyl, substituted phenyl, or a combinaton of these groups; Y and Z are each, independently, -CH2- or -C(O)-; R<1> - R<1><4> are each, independently, H or alkyl having 1 to 20 carbon atoms; R<7>, R<8> and R<1><4> may also be aryl or aralkyl, and R<3>, R<9>, R<1><1>, R<1><2> and R<1><3> may also be aralkyl; m, n and p are each, independently, 0 or an integer from 1 to 2; q is 0 or an integer from 1 to 4; and the dotted line represents an optional double bond. |
| priorityDate | 1994-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 482.