http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-7594-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d4a4ade7655d64fbb34e9232ced561da |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-54 |
| filingDate | 1994-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47d20e397fd2666d2893bde700cd2f78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52dd56b21508533aca0363824960a1e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e39c322905f77d64932c412d027b895b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78bbfcb15e14100595746b5c2f35dc38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_949e4d45229d4fb2b5d0c2054937e60e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8933b1a136849b99df3cf392e84325c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_165c558a54f0002b4789070fda2f0315 |
| publicationDate | 1995-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CZ-7594-A3 |
| titleOfInvention | Process for preparing phosphonium salts |
| abstract | In the present invention there is described a process for preparing phosphonium salts of the general formula I, in which R represents an alkyl group containing 1 to 4 carbon atoms, being optionally substituted with 1 to 2 fluorine atoms or an alkoxy group containing 1 to 3 carbon atoms, Re1 represents alkyl, alkenyl, alkynyl containing 2 to 6 carbon atoms or cycloalkyl, containing 5 to 10 carbon atoms or an cycloalkenylalkyl group having 5 to 10 carbon atoms, wherefrom 2 to 6 carbon atoms form the alkyl moiety, Re2 represents a hydrogen atom or tetrahydropyran-2-yl, trialkylsilyl, 1-ethoxyethyl-, 1-metyl-1-methoxyethyl group and X represents iodine or bromine atom. These compounds are significant intermediates in synthesis of therapeutically interesting prostaglandins being modified in {omega}-chain. These are especially preparations exhibiting cytoprotective activity and which are used for prevention and treatment of ulcerous disease of esophagus, stomach and duodenum induced by antipyretics based on salicylates and non-steroidal antiphlogistic medicaments based on arylacetic and propionic acids. The present invention is characterized by novel synthesis process of phosphonium salts, where the starting compounds are 1-substituted 3-oxoalkanes, which are treated in a medium of an ether solvent with a corresponding alkyl, alkenyl, and alkynyl magnesium halide. In the obtained substituted tertiary alcohol the original substituent is substituted either directly or after protection of the hydroxyl function with iodine or bromine atom and by treatment with triphenylphosphine in an organic solvent medium and at elevated temperature a corresponding phosphonium salt of the above specified general formula I is obtained in high yield. |
| priorityDate | 1994-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 107.