| abstract |
The procedure described in this patent is based on that principle, that the polysaccharide in a form of H+ is suspended in dimethylformamide containing no water, it is cooled to he temperature of 0 Celsius degrees, the equimolar amount of triethyl amine and isobuthyl formiate is added, it is incubated for 15 up to 30 minutes, solution with biological activity, in molar ration 1 up to 1000 : 1, according to polysaccharide is added, and it is incubated. The substance with a biological activity is bound to polysaccharide via amidic bond, being able to be degraded in vivo. |