http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-70492-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed35b7d3c96b10a9f0eec4e87a5c0847 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 |
| filingDate | 1992-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ad9e6d98baf657a515cda06cd3cefe6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9d819b3da747658dc2e8cb5628dc95c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42d413df68777d19aff5a6c540f86af8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a046b8b26d7ade4746a568d88ad6785a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13e102e40282a4bbf2c74ae73c2d66d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c49b14ddf4562fa57a4e1283cdae9316 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c814507b96a142d56057556510535fa0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_040ceb749d0c2a5cf4463d43cf2a3fd2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66584358e447679bbe87afab671d60e9 |
| publicationDate | 1993-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CZ-70492-A3 |
| titleOfInvention | Analogs of carboxy-terminal octapeptide (b-23-b-30) of a human insulin chain with a modification in positions b-24 and b-25 |
| abstract | The synthetic analogues of the carboxyterminal sequence of the B-chain of human insulin with a variation of amino acids in position B-24 and/or in position B-25 of the general formula:Gly-X-Y-Tyr-Thr-Pro-Lys-Thr23 24 25 26 27 28 29 30whereX is D-Phe Y is D-Phe (substance I)X is L-Phe Y is L-p-MePhe (substance II)X is L-Phe Y is D-p-MePhe (substance III)X is L-Phe Y is L-p-EtPhe (substance IV)X is L-Phe Y is D-p-EtPhe (substance V)X is L-p-MePhe is L- Phe (substance VI)X is D-p-MePhe Y is L- Phe (substance VII)X is L-p-EtPhe Y is L- Phe (substance VIII)X is D-p-EtPhe Y is L- Phe (substance IX)The substances are prepared by synthesis on a solid phase using the Boc/Biz protective strategy from the hydroxylbenztriazolic esters of individual amino acids whose possible side hydroxyls are protected, the hydroxyl of tyrosine by the 2.5-dichlorobenzyloxycarbonyl group, and the hydroxyl of threonine by the benzyl group. |
| priorityDate | 1992-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 160.