| abstract |
The present invention relates to various compounds of the formula I,n n where nX is OH, O, NOH, NH₂, loweralkylamino, cycloalkylamino, narylloweralkylamino or arylamino; nR₁ is H, loweralkylcarbonyl, arylcarbonyl, arylloweralkylcarbonyl, loweralkyl or arylloweralkyl; nR₂ is hydrogen, loweralkyl, cycloalkyl, arylloweralkyl, aryl; and R₃ when present is hydrogen, loweralkyl, cycloalkyl, arylloweralkyl or aryl with the proviso that, if X is OH or NH₂, R₁, R₂ and R₃ may not all be hydrogen; nand if X = O, R₂ may not be hydrogen and R₁ may not be 2,2-dimethylpropionyl; nand a process for their preparation. n The compounds of the invention are useful for the treatment of various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease, as topical antiinflammatory agents for the treatment of various dermatoses and also as analgesic agents. |