http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-34697-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f7b463a881c360b9d0189d5c53792d18 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-397 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 1997-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cae5ef0dc935e88574e2861b45923930 |
| publicationDate | 1997-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CZ-34697-A3 |
| titleOfInvention | Derivatives of 3-bromo and 3,3-dibromo-4-oxo-1-azetidines, process of their preparation and their use |
| abstract | The invention relates to derivatives of 3-bromo- and 3,3-dibromo-4-oxo-1-azetidines of general formula I to processes for the preparation thereof and the use thereof. <CHEM> wherein <CHEM> wherein R4 is hydrogen, methyl, benzyl or some other protective group, R5 is hydrogen, alkyl, alkylaryl, a heterocyclic ring, Y is halo atom, X is halo atom, alkoxy group, nitroxy group. According to the invention derivatives of 3-bromo- and 3,3-dibromo-4-oxo-1-azetidines are prepared by the reaction of 2-sulfinic acid derivatives, preferably 2-substituted sulfinamides of 4-oxo-azetidines with various halogenating agents, and after the treatment of the reaction mixture, 2-halo derivatives of 3-bromo- and 3,3-dibromo-4-oxo-azetidines are isolated and are subjected to a reaction with silver tetrafluoroborate and alcohols to give the corresponding 2-alkoxy derivatives of 3-bromo- and 3,3-dibromo-4-oxo azetidines, or 2-halo derivatives of 3-bromo- and 3,3-dibromo-4-oxo azetidines are subjected to a reaction with silver nitrate in 2-propanol to give, after the treatment of the reaction mixture, 2-nitroxy derivatives of 3-bromo and 3,3-dibromo-4-oxo-1-azetidines. Some newly prepared compounds are deprotected and derivatives having a free carboxy group are obtained. The prepared compounds are components in pharmaceutical compositions effective in antibacterial or antitumour therapy. |
| priorityDate | 1996-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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