http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-323792-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ecb75d86a7b128c707265e9e7a5d844a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D319-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-66 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4738 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-541 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 |
| filingDate | 1992-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94cb4667174e11ddddc883ad2cc5bf8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_466c812923f7ca34c50da737e1042600 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29eef37ea2471eb241ba8820b704d631 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcfc22b1638e139ab204f48cb5dac3d3 |
| publicationDate | 1993-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CZ-323792-A3 |
| titleOfInvention | Water-soluble derivatives of camptothecin, process of their preparation and pharmaceutical preparations in which they are comprised |
| abstract | The invention relates to water soluble, camptothecin derivatives of formula (I), <CHEM> wherein: n represents the integer 1 or 2; and i) R<1> and R<2> represent independently, hydrogen, lower alkyl, (C<7> PI 1/2 )cycloalkyl, (C<7> PI 1/2 )cycloalkyl lower alkyl, lower alkenyl, hydroxy lower alkyl, lower alkoxy lower alkyl; ii) R<1> represents hydrogen, lower alkyl, (C<7> PI 1/2 )cycloalkyl, (C<7> PI 1/2 )cycloalkyl lower alkyl, lower alkenyl, hydroxy lower alkyl or lower alkoxy lower alkyl, and R<2> represents -COR<3> wherein R<3> represents hydrogen, lower alkyl, perhalo-lower alkyl, (C<7> PI 1/2 )cycloalkyl, (C<7> PI 1/2 )cycloalkyl lower alkyl, lower alkenyl, hydroxy lower alkyl, lower alkoxy, lower alkoxy lower alkyl; or iii) R<1> and R<2> taken together with the linking nitrogen form a saturated 3 to 7 atom heterocyclic group of formula (IA) <CHEM> wherein: Y represents O, S, CH<6>, NR4 wherein R4 represents hydrogen, lower alkyl, perhalo-lower alkyl, aryl, aryl substituted with one or more lower alkyl, halogen, nitro, amino, lower alkyl amino, perhalo-lower alkyl, hydroxy lower alkyl, lower alkoxy, lower alkoxy lower alkyl groups or; -COR5 wherein R5 represents hydrogen, lower alkyl, perhalo-lower alkyl, lower alkoxy, aryl, aryl substituted with one or more lower alkyl, perhalo-lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl groups; and the pharmaceutically acceptable salts thereof; their use in the treatment of tumors and methods of their preparation. |
| priorityDate | 1991-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 161.