| abstract |
The present invention relates to a process for the preparation of a sofosbuvir of formula (II) which comprises reacting a compound of formula (IV) activated with a suitable reagent with a compound of formula (I) wherein R a R can be independently H, C 1 -C 6 branched or unbranched alkyl, C 1 -C 6 branched or unbranched alkoxy, C 1 -C 6 C 6 branched or unbranched alkylsulfanyl, C 1 -C 6 branched or unbranched monoalkylamino- or dialkylamino, pyrrolidino, piperidino or morpholino. |