| abstract |
The present invention provides novel tacrine and tryptophan-based conjugates of Formula I, and pharmaceutically acceptable alkali metal, ammonium or amine salts thereof, or acid addition salts thereof, wherein n is 2 to 8, R 5. is O (C 1-6 alkyl-, C 1-6 alkyl) or H and R 5 are n. is H, Cl or Br, provided that when R.sup.1 is n. OCH.sub.3.n., R.sup.2.n. at the same time it cannot be Cl. It further provides a method for their preparation and their therapeutic use. |