| abstract |
Substituted 7-deazapurine ribonucleosides of formula I wherein R is methylsulfanyl, methoxy-, methylamino- or dimethylamino- and R 'is furan-2-yl, furan-3-yl, thiophen-2-yl, thiophene-3- yl, phenyl, benzofuran-2-yl, ethynyl or iodine, or an optical isomer thereof, or a mixture of such optical isomers, provided that when R 1 is iodo, R is not methoxy. The compounds of the present invention exhibit potent cytostatic and cytotoxic effects on cell lines of preferential tumor origin, on a wide range of diseases including tumors of various histogenetic origin. |