| abstract |
A pharmaceutical formulation comprising a beta-carboline active compound of formula I which is in the form of free drug particles, at least 90% of which have a particle size of less than 10 µm; 50 to 85% by weight of a water-soluble diluent; lubricant; 1 to 5% by weight of a hydrophilic binder selected from the group consisting of a cellulose derivative, povidone and mixtures thereof; and a disintegrant selected from the group consisting of croscarmellose sodium, crospovidone and a mixture thereof, wherein the free drug is understood to be solid particles that are not tightly embedded in the polymeric coprecipitate. This formulation for use in the treatment of sexual dysfunction, selected in particular from male erectile dysfunction and female arousal disorder. |