| abstract |
A solid bleeding arrest, tissue sealing and tissue bonding composition comprising a collagen carrier, fibrinogen and thrombin consisting of a collagen carrier having at least two of the physical properties of which the modulus of elasticity is in the range of 100 to 500 kPa, density 1 to 10 mg / cm.sup.3.n. and a cavity diameter greater than 0.75 mm and less than 4 mm and / or a mean cavity diameter below 3 mm; wherein the mixture is evenly distributed and anchored on said carrier; b) solid human fibrinogen; and c) solid human thrombin. This device for use in gastrointestinal surgery, parenchymal organs, cardiovascular surgery, chest surgery, ear, nose and throat surgical interventions, including dental surgery, gynecological, urological, vascular, bone surgery, and urgent surgery, neurological surgery, lymphatic, biliary and cerebrospinal fistulas, and air leaks during chest and lung surgery. |