| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5305109c4efec4cbcdd8bc05bdb00399 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-10 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4184
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4245
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B37-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D271-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-10 |
| filingDate |
2011-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9823889dd90f9c9a56c2e9403b99c16 |
| publicationDate |
2014-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CZ-304252-B6 |
| titleOfInvention |
Method for the preparation of 2-ethoxy-1 - ((2'- (5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl) biphenyl-4-yl) methyl) -1H-benzo [d imidazole-7-carboxylates and converting them to azilsartan |
| abstract |
The present invention relates to a process for the preparation of alkyl 2-ethoxy-1 - ((2'- (5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl) biphenyl-4-yl) methyl) - 1 H -benzo [d] imidazole-7-carboxylates of the formula I wherein R is either branched or unbranched C 1 -C 4 alkyl ArCH 2, Ar 2, CH 3, or Ar.sub. 3.nC, where Ar is a substituted or unsubstituted phenyl, by reacting alkyl 2-ethoxy-1 - ((2 '- ((hydroxyamino) iminomethyl) biphenyl-4-yl) methyl) -1H-benzo [d] imidazole-7- a carboxylate of formula V with a cyclizing agent in a solvent in the presence of suitable bases and converting them to azilsartan. |
| priorityDate |
2011-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |