| abstract |
A replication defective monkey adenoviral vector that contains monkey adenovirus cis-elements in the capside of the monkey adenovirus and a heterologous gene operably linked to expression control sequences wherein the monkey adenovirus capsid is derived from a simpanic adenovirus selected from the group consisting of Pan 5, Pan 6 and Pan 7. A method for producing this vector, which comprises combining the heterologous gene and the ITR sequence of the monkey element of the adenovirus. A medicament, immunogenic composition and vaccine, particularly for inducing a cytotoxic immune response comprising the above recombinant adenovirus. |