| abstract |
A novel process for producing iopamidol, chemically (S) -N, N'-bis [2-hydroxy-1- (hydroxymethyl) ethyl] -5 - [(2-hydroxy-1-oxopropyl) amino] -2,4, is described, 6-triiodo-1,3-benzenedicarboxamide. The starting material used is the corresponding 5-unsubstituted amino derivative. By using this intermediate, it is possible to obtain the resulting high optical purity iopamidol under inerting conditions. |