http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-303061-B6
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5305109c4efec4cbcdd8bc05bdb00399 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-04 |
| filingDate | 2010-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_109ad51e17eca3f7e0a85a6d9081b91d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57026ba0204ad0b3c7a610822b985b44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67ba19c3ee4da971b4ecfe53d9915ae4 |
| publicationDate | 2012-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CZ-303061-B6 |
| titleOfInvention | The process for producing (-) - 1- (3-hydroxypropyl) -5 - [(2R) -2 - ((2,2,2-trifluoroethoxy) phenoxyethyl} amino) propyl] -2,3-dihydro-1H-indole- 7-carboxamide |
| abstract | The present invention relates to a new process for the preparation of (-) - 1- (3-hydroxypropyl) -5 - [(2R) -2 - ((2,2,2-trifluoroethoxy) phenoxyethyl} amino) propyl] -2,3-dihydro The 1 H -indole-7-carboxamide of formula I, also known as silodosin, and its salts, proceeding in 4 steps: step A is alkylation of a secondary amine of formula II, an alkylating agent of formula III, step B is N-hydrogenolysis the tertiary amine of formula IV with hydrogen on a metal catalyst, step C is the hydrolysis of the nitrile of formula V by treatment with alkali, and step D is the O-debenzylation of the amide ether of formula VI with hydrogenolytic or trialkylsilyl halide reagents. |
| priorityDate | 2010-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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