| abstract |
Lincomycin derivatives are prepared by biotechnological cultivation of Streptomyces lincolnensis ATCC 25466, which has an inactivated lmbJ gene and / or at least one gene from the lmb gene family of lmbA, B1, B2, W, X and Y genes encoding 4-L-propylproline biosynthesis. If 4-L-propylproline biosynthesis is blocked, a replacement for this intermediate must be added to the culture medium. Thus, biosynthesis produces new biologically active lincomycin derivatives. |