| abstract |
Piperidinopiperidyl derivatives useful as CCR5 antagonists of Formula II, or pharmaceutically acceptable salts thereof, wherein the substituents are as defined in the claims, their use in the manufacture of a pharmaceutical composition for the treatment of HIV, rejection of transplanted solid organ, host graft rejection, arthritis, articular rheumatism, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis. New pharmaceutical compositions comprising these derivatives and a combination of a CCR5 antagonist of the present invention in combination with antiviral agents useful for HIV treatment or agents useful in the treatment of inflammatory diseases. |