| abstract |
The compounds of formula I and their salts with mineral or organic acids, their solvates and / or hydrates, which show a strong affinity and a high degree of selectivity for human NK.sub.1.n. Substance P receptors, process for the preparation of these compounds, pharmaceutical compositions containing these derivatives and their use in the manufacture of medicaments for the treatment of all pathological conditions associated with Substance P and / or human NK.sub.1.n. receptors such as respiratory, gastrointestinal, urinary, immune, cardiovascular and central nervous system diseases. |