| abstract |
The invention relates to condensates of 2-aminothiazole-2-aminoindanes and 2-aminothiazole-2-aminotetralins of the general formula 1, in which R.sub.1.n. and R 2, which may be identical or different, are selected from the group consisting of hydrogen atoms, (C 1 -C 7) alkyl, (C 1 -C 7) haloalkyl (C 1 -C 7) alkyl, (C 3 -C 7) alkenyl, (C 3 -C 6) alkenyl or (C 3 -C 6) alkynyl, (C 1 -C 3) arylalkyl group in the alkyl radical, wherein the aryl core is selected from the phenyl radical; naphthyl, 2-naphthyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-thienyl, 3-thienyl, 2-furanoyl, 3-furanoyl, 2-imidazolyl, 4- an imidazolyl radical and a 1-imidazolin-2-one radical, and may be substituted by a fluorine atom, a chlorine atom, a bromine atom or a sulfonyloxy group, with the meaning 1 or 2; and their acid addition salts and their enantiomers, as well as pharmaceutical compositions containing them and their use in the manufacture of medicaments having an impact on the central nervous system dopaminergic and / or circulatory system and for the treatment of schizophrenia and Parkinson's disease or parkinsonism. |